Press release
Jul 29, 2004

Announcement of Movement in Major Shareholders

[Tokyo, Japan/London, UK] Sosei Co. Ltd., a Japanese biopharmaceutical company, announces the movement in its major shareholders holding more than 5% of the shares as of 29 July.

- Reasons of the movement

  1. Increase of the total number of capital stock due to the new shares issued upon IPO.

  2. Share offering by the concerned major shareholder upon IPO

- Concerned Holder of the Movement

  Name: Shinichi Tamura        Address: Satoyamabe, Matsumoto, Nagano Pref. Japan

- Changed items of the concerned shareholder

                               Number of the voting rights (number of shares)    Percentage of its voting rights in the total shareholders                      Majority rank

Before movement       4,845                                                                                                     10.27%                                                                     1st
(28 July 2004)

After movement         3,645                                                                                                        5.95%                                                                     2nd
(29 July 2004)

Note 1: The 1st major shareholder after movement is the Tokyo Marine and Fire Securities Insurance, Ltd. (4,000 of the voting rights, 6.53% of the total). Note 2: The number of all-issued stock is 61,220. - END – Sosei Co. Ltd. 4F Ichiban-cho FS Bldg., 8 Ichiban-cho, Chiyoda-ku, Tokyo 102-0082