A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines.

Soave, M, et al.

2017 Biochem Pharmacol. 2017 Nov 2;147:38-54. https://www.sciencedirect.com/science/article/pii/S0006295217306469?via%3Dihub