Sosei Heptares group welcomes you to CHISHIKI, the destination for updates on our progress in the world of GPCRs. CHISHIKI is the Japanese word for “knowledge.” CHISHIKI is our online voice for communicating the scientific progress of our research and development activities, together with our broader contributions to the area of GPCRs.
Manipulation of allosteric mechanisms in GPCR drug design
By Stacey Southall | Aug 3, 2018
We attended "Structure and Mechanism of Membrane Proteins", a Biochemical Society meeting on August 2-3, 2018 at Maple House in Birmingham UK, and presented recent case studies of allosteric modulators of GPCRs where Sosei Heptares StaR technology has enabled structural and biophysical characterisation of allosteric binding pockets and the mode of modulation on GPCRs. We explain how understanding of this diverse range of sites and mechanisms opens new avenues in SBDD towards generation of GPCR targeted drugs with improved therapeutic profile.READ MORE...
Beyond the Happy Water
By Ben Tehan | Apr 11, 2018
We presented our research on water molecules and recent advances in the quantification of their contributions at "Structure-Activity Relationships".READ MORE...