Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 negative allosteric modulator HTL14242 (3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).

Christopher, JA, Aves, SJ, Bennett, KA, Doré, AS, Errey, JC, Jazayeri, A, Marshall, FH, Okrasa, K, Serrano-Vega, MJ, Tehan, B, Wiggin, GR & Congreve, M.

2015 J. Med. Chem. 2015, 58: 6653-6664. https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.5b00892